![]() #HOWEVER SYN MANUAL#We then report the correlation of volumes gained by algorithmic cortical labelings of FTD and control subjects with those gained by the manual rater. The new method compares favorably with both approaches, in particular when the distance between the template brain and the target brain is large. Our evaluation uses gold standard, human cortical segmentation to contrast SyN’s performance with a related elastic method and with the standard ITK implementation of Thirion’s Demons algorithm. We then turn to a careful evaluation of our method. Here, we develop a novel symmetric image normalization method (SyN) for maximizing the cross-correlation within the space of diffeomorphic maps and provide the Euler-Lagrange equations necessary for this optimization. These spatiotemporal signals will aid in discriminating between related diseases, such as frontotemporal dementia (FTD) and Alzheimer’s disease (AD), which manifest themselves in the same at-risk population. Quantifying spatial and longitudinal atrophy patterns is an important component of this process. On the flip side, the real estate sector had the biggest loss this week, down 4.2%.One of the most challenging problems in modern neuroimaging is detailed characterization of neurodegeneration. It outpaced the other 11 sectors by a wide margin with a gain of 13.9%. The surge in oil prices contributed to the S&P 500 energy sector’s gains this week. This sent oil prices surging with WTI crude oil futures rising 17.3% this week to $93.20/bbl. Geopolitical worries were also in play this week after OPEC+ announced a production cut of 2 million barrels per day starting in November. Atlanta Fed President Bostic (2024 FOMC voter) said the inflation fight is still in the early days and Minneapolis Fed President Kashkari (2023 FOMC voter) said he is not comfortable pausing until there is evidence of inflation cooling. There was also some hawkish Fed speak this week for participants to digest. The September Employment Report reflected continued strength in the labor market, stoking concerns about continued aggressive rate hikes from the Fed. The S&P 500 was up 1.5% the Dow Jones Industrial Average was up 2.0% the Nasdaq Composite was up 0.7%. Notably, the stock market was able to hang onto some of its gains this week despite heavy losses on Friday. The 10-yr note yield rose eight on the week to 3.88%. The 2-yr note yield rose and ten on the week to 4.30%. The week ended with a broad sell off, however, after Treasury yields moved up considerably and the September Employment Report threw cold water on the idea that the Fed would be less aggressive sometime soon. The idea that the Fed would soften its approach soon gained traction following weaker-than-expected ISM Manufacturing and Construction Spending data out of the U.S., and a 25 basis point rate hike from the Reserve Bank of Australia versus the expected 50 basis points. At the same time, the S&P 500, Dow Jones Industrial Average, and the Nasdaq Composite logged gains of 5.7%, 5.5%, and 5.7%, respectively. The 2-yr note yield settled at 4.20% last Friday and fell to 4.08% by Tuesday’s close. The 10-yr Treasury note yield settled at 3.79% last Friday and fell to 3.62% by Tuesday’s close. ![]() A pullback in Treasury yields from last Friday’s closing levels helped fuel upside momentum in the beginning of the week. There was a massive rally on Monday and Tuesday as the market bought into the idea that the Fed would soften its approach sometime soon. The equity market had a strong start to the week, month, and fourth quarter. ![]()
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